Markku Koulu Selected Research

Protein Sorting Signals (Signal Peptide)

3/2007	Leucine 7-proline 7 polymorphism in the signal peptide of neuropeptide Y is not a risk factor for exudative age-related macular degeneration.
9/2004	Leucine7 to proline7 polymorphism in prepro-NPY gene and femoral neck bone mineral density in postmenopausal women.
2/2004	Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with proteinuria, coronary heart disease, and glycemic control in type 1 diabetic patients.
1/2004	Neuropeptide Y and Y2-receptor are involved in development of diabetic retinopathy and retinal neovascularization.
7/2003	Changes in diurnal sympathoadrenal balance and pituitary hormone secretion in subjects with Leu7Pro polymorphism in the prepro-neuropeptide Y.

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Markku Koulu Research Topics

Disease

6	Body Weight (Weight, Body) 01/2016 - 10/2003
4	Atherosclerosis 04/2009 - 04/2003
3	Glucose Intolerance 01/2016 - 06/2008
3	Diabetic Retinopathy (Retinopathy, Diabetic) 02/2004 - 07/2003
2	Type 2 Diabetes Mellitus (MODY) 01/2020 - 01/2004
2	Gestational Diabetes (Gestational Diabetes Mellitus) 01/2020 - 01/2013
2	Weight Gain 01/2016 - 10/2003
2	Obesity 01/2016 - 10/2003
2	Vascular Diseases (Vascular Disease) 04/2009 - 06/2005
2	Genetic Predisposition to Disease (Genetic Predisposition) 02/2004 - 01/2004
1	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 01/2013
1	Vascular System Injuries 04/2009
1	Hyperplasia 04/2009
1	Hypertension (High Blood Pressure) 01/2009
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 06/2008
1	Hyperphagia (Overeating) 06/2008
1	Macular Degeneration (Age-Related Maculopathy) 03/2007
1	Birth Weight (Birth Weights) 11/2006
1	Cardiovascular Diseases (Cardiovascular Disease) 11/2006
1	Osteoporosis 09/2004
1	Coronary Disease (Coronary Heart Disease) 02/2004
1	Diabetic Nephropathies (Diabetic Nephropathy) 02/2004
1	Proteinuria 02/2004
1	Retinal Neovascularization 01/2004
1	Hyperoxia 01/2004
1	Hyperandrogenism 10/2003
1	Follicular Cyst (Follicular Cysts) 10/2003

Drug/Important Bio-Agent (IBA)

7	Neuropeptide YIBA 01/2016 - 01/2004
5	Protein Sorting Signals (Signal Peptide)IBA 03/2007 - 07/2003
4	Metformin (Glucophage)FDA LinkGeneric 01/2020 - 01/2013
4	Leucine (L-Leucine)FDA Link 06/2008 - 07/2003
3	Proline (L-Proline)FDA Link 06/2008 - 07/2003
3	Triglycerides (Triacylglycerol)IBA 06/2008 - 02/2004
3	preproneuropeptide YIBA 02/2004 - 07/2003
2	Pharmaceutical PreparationsIBA 01/2020 - 01/2004
2	CholesterolIBA 01/2016 - 04/2003
2	Glucose (Dextrose)FDA LinkGeneric 01/2016 - 01/2013
2	LipidsIBA 02/2004 - 07/2003
1	Hypoglycemic Agents (Hypoglycemics)IBA 01/2013
1	Dopamine beta-HydroxylaseIBA 04/2009
1	Neurotransmitter Agents (Neurotransmitter)IBA 04/2009
1	Hormones (Hormone)IBA 06/2005
1	LeptinIBA 05/2004
1	Vasoconstrictor AgentsIBA 02/2004
1	AlbuminsIBA 02/2004
1	Messenger RNA (mRNA)IBA 01/2004
1	Antisense OligonucleotidesIBA 01/2004
1	AndrogensIBA 10/2003
1	Human beta Subunit Chorionic GonadotropinIBA 10/2003
1	Luteinizing Hormone (Lutropin)FDA LinkGeneric 10/2003
1	Cytidine Triphosphate (CTP)IBA 10/2003
1	beta Subunit Luteinizing HormoneIBA 10/2003

Therapy/Procedure

1	Hormone Replacement Therapy (Therapy, Hormone Replacement) 09/2004
1	Glycemic Control 02/2004
1	Ovariectomy (Oophorectomy) 10/2003